Mexico and the United States are celebrating 200 years of diplomatic relations. At the Mexican Ministry of Foreign Affairs we have prepared a program of celebrations that is, above all, a space for plural reflection. The bicentennial is a once-in-a-lifetime opportunity to ask ourselves what lessons we should learn from the past, what is the current state of the relationship, and which path going forward will strengthen our binational ties, consolidate North America as a region globally, and advance the interests of Mexico abroad. This commemorative issue of the Revista Mexicana de Política Exterior is a clear example of this exercise in critical discussion throughout our shared history.